Opening image: The heptameric GroEL ring. Click here to view down the seven-fold axis of symmetry. The ring is shown in the closed conformation (no ADP).
Click here to change to side view. rotation.
During the '90s the bacterial GroE chaperone became the paradigm of a protein folding machine. This lesson explores the architecture of the GroEL and GroES subunits and their assembly into heptameric rings.